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If you are concerned about acne whilst taking B12 supplements, it is advisable to discuss this with your GP rather than discontinuing treatment without medical guidance, particularly if the B12 has been prescribed to address a documented deficiency

1997 Nov;23(4):739-55

The full mechanism and research are covered in the 5-Amino-1MQ complete guide

H.StahlE.ErdmanR.GatalicaZ.et al (2015)