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The oxidative stress induced by CS activates pathways involving NF-, MAPK, and NLRP3 inflammasome activities [17]

Type I and II endometrial cancers: have they different risk factors

The core mechanism underlying the interplay between ferroptosis and pyroptosis is as follows: mitochondrial damage-associated molecular patterns released during ferroptosis, such as mitochondrial DNA and ROS, can be recognized by the NLRP3 inflammasome, leading to caspase-1 activation and subsequent cleavage of gasdermin D to form plasma membrane pores, thereby executing pyroptosis and releasing mature IL-1 and IL-18 (7376)

Arq Neuropsiquiatr 68:362366