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Greenamyre JT
Although O 2 is not a strong oxidant, it is still potentially toxic
Indeed, methotrexate therapy does diminish polyamine levels in the joints of patients with RA [2830], but this effect, like that of methotrexate on T-cell proliferation, is reversed by folic acid
[DOI] [PMC free article] [PubMed] [Google Scholar] Henricks P
