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Time in the era of immunotherapyNew molecular insights into the immunosuppression mechanism of lymphocyte activation gene-3

445 Immunotherapeutic treatments have shown significant efficacy in TNBCs due to tumor immune infiltration, neoantigens caused by mutational burden and higher genomic instability, and high levels of immune markers such as PD-L1 and programmed cell death 1 (PD-1)

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A small number of GHR antagonists have been used in an oncology settings in preclinical studies and the growth-inhibiting effects have been reported in colon, breast, and meningioma tumor xenografts, which suggested that GHR antagonism as a monotherapy is efficient in some tumor types (Friend, 2001