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Some clinical studies have found elevated lactate levels (395, 396) in ME/CFS patient blood, cerebrospinal fluid, and muscles, suggesting there is reduced oxidative phosphorylation and a switch to anaerobic glycolysis (392, 397399)

Shortly after the discovery of these homodimers, Jones et al

A comprehensive review on NIH/PMC documents that GHK-Cu cream applied twice daily for 12 weeks strongly stimulated dermal keratinocyte proliferation, increased skin thickness, improved skin hydration, increased collagen I production and improved skin elasticity in clinical study participants

Drawbacks: Injections require a visit to a healthcare professional, can be uncomfortable, and are often more expensive than supplements