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BPC-157 meets this criterion because its clinical development (PL 14736, Diagen) stalled at phase II in 2014 and never obtained registration as a drug

The pathway it uses relates to reorganisation of intracellular structure and movement of the cell through tissues

Another interesting compound, quercetin, has been shown to inhibit the activity of CD38 by binding to its active site, which results in increased intracellular NAD + 143

For readers exploring intestinal permeability science, this distinction matters because research focuses on measurable barrier regulation, not broad or fear-based claims about leaky gut. To understand this properly, it helps to begin with the structural foundation of the gut barrier: "Gut Barrier Health: Science of Intestinal Integrity" What Is Intestinal Permeability (Scientifically)