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Koenitzer J

2014 Nov 19;19(11):19066-77.

The results demonstrated that TSA concentration-dependently enhanced IKs current amplitude (EC50=64.5 M), accelerated channel activation kinetics, slowed inactivation and shifted the voltage dependence of IKs activation toward hyperpolarization (134)

Investigators are particularly interested in determining the mechanisms by which effects observed in murine models relate to broader mammalian metabolic regulation, and whether different experimental conditions (young vs aged models, healthy vs metabolically compromised states) show differential responses to NNMT inhibition