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Abstract Introduction: Vitamin B 12 deficiency is a growing health concern, affecting millions worldwide

Furthermore, local targeting of NAD + salvage pathway by microparticle-mediated intratumoral delivery of NAMPT inhibitor GMX1778 induced striking immunologic changes in the tumor microenvironment of murine glioblastoma, characterized by upregulation of immune checkpoint PD-L1, recruitment of cytotoxic T cells, and reduction of tumor-associated macrophages, and potentiated checkpoint immunotherapy [114]

doi: 10.1016/j.abb.2019.108241 56 LiuQSunLTanYWangGLinXCaiL

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