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Apoptosis is initiated by intrinsic and extrinsic pathways

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Mansour MA, Ginawi OT, El-Hadiyah T, El-Khatib AS, Al-Shabanah OA, Al-Sawaf HA (2001) Effects of volatile oil constituents of Nigella sativa on carbon tetrachloride-induced hepatotoxicity in mice: evidence for antioxidant effects of thymoquinone

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Through intricate crosstalk with these diverse signaling cascades, HIF-1 modulates the secretion of inflammatory factors and participates in the regulation of various cellular processes, including survival, proliferation, metabolism, angiogenesis, and inflammatory responses

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