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2009;2009 doi: 10.1136/bcr.06.2008.0114
Currently, magnesium sulfate is the only therapeutic with established neuroprotective effects for preterm births before 32 weeks of gestation that can be administered antenatally ( Approximately 90% of the drug candidates that enter clinical trials fail to gain regulatory approval and reach the market ( effects in utero, it is important to unravel the maternal, placental, and fetal contribution to the processing of toxicants and therapeutic agents

[DOI] [PMC free article] [PubMed] [Google Scholar] 75.Klaus A., Zorman S., Berthier A., Polge C., Ramirez S., Michelland S., Sve M., Vertommen D., Rider M., Lentze N., Auerbach D., Schlattner U

64 , 65 In murine MM models, inhibiting HIF1 downregulated proangiogenic genes, including vascular endothelial growth factor, and led to a reduction in the weight and volume of the tumor burden
