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Two trials examining the effects of nicotinamide riboside and low-dose naltrexone (LDN) are currently underway (NCT04809974, NCT04604704) to reduce cognitive symptoms and fatigue by regulating inflammatory responses (Omran and Almaliki, 2020)

Acknowledgements This work was supported by the National Natural Science Foundation of China (21102182), the Natural Science Foundation of Jiangsu Province (BK2012760, China), Fundamental Research Funds for the Central Universities (2632018ZD09, China), and Excellent Science and Technology Innovation Team of Jiangsu Province Universities in 2015 (China)

For real deficiency correction, injections remain the more reliable treatment

Morquette et al