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However, inherent differences exist in gut microbiota composition and immune cell response patterns between rodents and humans, leading to insufficient cross-species validation of core mechanisms

When selecting a BMD as a POD, EPA should provide justification for selecting a response level (e.g., at the 10%, 5%, or 1% level)

Cell Mol Life Sci 2016;73:234967 [DOI] [PMC free article] [PubMed] [Google Scholar] 55.Manakkat Vijay GK, Ryan JM, Abeles RD, Ramage S, Patel V, Bernsmeier C, Riva A, McPhail MJ, Tranah TH, Markwick LJ, Taylor NJ, Bernal W, Auzinger G, Willars C, Chokshi S, Wendon JA, Ma Y, Shawcross DL.Neutrophil toll-like receptor 9 expression and the systemic inflammatory response in acetaminophen-induced acute liver failure

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