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Sittipunt, C
JCO 33, 2512
Surviving HIV infected macrophages have reduced overall mitochondrial function but maintain their stress response To determine whether HIV targets mitochondrial metabolism during different stages of HIV infection of human primary macrophages, we measured their oxygen consumption rate (OCR) using a SeaHorse analyzer (Agilent Technologies, Santa Clara, CA) to determine basal respiration, ATP production, proton leak, maximal respiration, and mitochondrial spare capacity (see details, As indicated in Fig
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