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Proteomics suggests that HOXA transcript antisense RNA myeloid-specific 1 (HOTAIRM1) is associated with mitochondrial function, and knockdown of HOTAIRM1 can increase the level of ROS and radiation sensitivity, thereby prolonging patient survival ( Apurinic/apyrimidinic endonuclease1 (APE1), associated with checkpoint kinase 2 (Chk2), participates in the coordination of double-strand break DNA repair

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They possess 2-O-methyl-modified 3 ends and form complexes with PIWI proteins, in contrast to miRNAs and siRNAs which pair with AGO proteins

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