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[DOI] [PMC free article] [PubMed] [Google Scholar] [9].Anrather J, Racchumi G, Iadecola C, NF-kappaB regulates phagocytic NADPH oxidase by inducing the expression of gp91phox
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By donating a reducing equivalent to other unstable molecules, such as ROS, GSH is readily converted to GSSG, which can be converted back to GSH by the enzyme glutathione reductase (GR) 29
This modulation is crucial during infections, where controlled ROS aid in pathogen killing
