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From a clinical perspective, it suggests that in disease states with high IL-5 (like hypereosinophilic syndromes or active IBD with a type 2 skew), targeting Siglec-8 could be especially effective in depleting pathogenic eosinophils

Li QM, Xu T, Zha XQ, Feng XW, Zhang FY, Luo JP (2024c) Buddlejasaponin IVb ameliorates ferroptosis of dopaminergic neuron by suppressing IRP2-mediated iron overload in Parkinsons disease

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doi: 10.1096/fj.07-102731 286 SafaiyanS.Besson-GirardS.KayaT.Cantuti-CastelvetriL.LiuL.JiH.et al
