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From a clinical perspective, it suggests that in disease states with high IL-5 (like hypereosinophilic syndromes or active IBD with a type 2 skew), targeting Siglec-8 could be especially effective in depleting pathogenic eosinophils

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Li QM, Xu T, Zha XQ, Feng XW, Zhang FY, Luo JP (2024c) Buddlejasaponin IVb ameliorates ferroptosis of dopaminergic neuron by suppressing IRP2-mediated iron overload in Parkinsons disease

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doi: 10.1096/fj.07-102731 286 SafaiyanS.Besson-GirardS.KayaT.Cantuti-CastelvetriL.LiuL.JiH.et al

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