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Excessive ROS can profoundly impair ovarian function by interfering with key hormonal pathways crucial for follicular development and ovulation

Briefly, the authors studied the GPx-like activity of ebselen under cell-free conditions using GSH-reduced nicotinamide adenine dinucleotide (NADH)-GR coupled assay

Future strategies will likely emphasize combinatorial regimens, optimized in terms of target hierarchy, temporal dynamics, and dosage to maximize benefit while minimizing adverse effects

In a perfect world, it would be vetted in well-designed human studies, widely prescribed by licensed professionals, and easily available at compounding pharmacies