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This could be due to the much greater numbers of brain AT 1 receptors, as compared with AT 2 receptors, such that the beneficial effects of AT 2 receptor activation was overwhelmed by AT 1 activation

This study was supported by the Sichuan Science and Technology Program (Award Number: 2023NSFSC 1802, Recipient: FY)
the use of an ineffective testing regime that missed obvious errors

Kalivas and Volkow identified alterations in glutamatergic signaling that result in an inability to alter ones behavior in cocaine addicts (Kalivas and Volkow, 2005, 2011
