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granulation) Tailored dressing selection based on exudate and infection status Consideration of advanced therapies (e.g., NPWT) in complex wounds Limb-Threatening Red Flags (Mandatory Recognition) Immediate specialist evaluation is required if: Rapidly increasing pain or tissue necrosis Malodor with systemic signs (fever, tachycardia) Suspicion of deep infection or osteomyelitis Signs of spreading cellulitis or sepsis Uncertainty Statement While hydrofiber and alginate dressings are widely recommended, direct comparative RCT evidence remains limited, notably regarding long-term healing endpoints and biofilm-specific outcomes

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