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These included (a) the generation of ROS and the build-up of oxidative stress, (b) the disruption of mitochondrial activity, (c) the association of Ag + with membranes and the production of peroxylipids, (d) the unfolding or misfolding of proteins leading to endoplasmic reticulum stress, (e) apoptosis and autophagy, (f) the activation of redox-sensitive MAPK pathways 8 and transcription factors such as AP-1, Nrf-2, and NF-kB, (g) the induction of DNA damage, (h) proinflammatory and profibrotic response in fibroblasts, and (i) the upregulated expression of metallothioneins and heme oxidase 1

Lemon is sour so should not make your salad dressing bitter, but olive oil is bitter

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