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There was no significant effect of chewing tobacco on the function of accessory gland, seen with a small number of 29 patients in a study, but a larger sample size could find a definitive conclusion on the damaging effects of tobacco.[28] However, seminal plasma of non-smokers could retrieve motility of sperms from smokers.[29] In intensive tobacco chewers, normal morphology was affected more than sperm count and motility, corroborated elsewhere.[8] Even though sperms with irregular acrosome, bent neck and coiled tail were observed in non-intensive tobacco chewers, additional anomaly of head defects and cytoplasm residues were found to be of higher degree in intensive chewing cases

This durability suggests that the medication provides lasting changes in how the brain responds to nicotine cravings