the chemical in tobacco that is addictive is Addiction: Nicotine and Other Factors, Animation What Makes Cigarettes Addictive: Is
Description
Toxicokinetics Nicotine, a weak base alkaloid (pKa = 8.5), is poorly absorbed from the stomach because it is ionised in the acidic gastric fluid, but is well absorbed in the small intestine, which has an alkaline pH and a large surface area 10 , 11
Ellison-Wright I, Bullmore ET
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For example, treating tobacco with endophytes or microbial inoculants can enhance its stress resistance
