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The presence of nicotine and other chemicals can impair healing, increase inflammation, and contribute to complications such as wound infections, respiratory issues, and anastomotic leaks

25 Desensitization ligand-induced closure and unresponsiveness of the receptor is believed to play a role in tolerance and dependence: the symptoms of craving and withdrawal begin in smokers when desensitized 4 2 * nicotinic cholinergic receptors become responsive during periods of abstinence, such as nighttime sleep

Still, it has a mean enough edge and an angled point instead of a curved one, better for stabbing