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POSSIBILITIES OF NEW TREATMENTS AGAINST ADDICTION The first pharmacotherapeutic interventions for smoking nicotine addiction consist of NRT, the 42 nicotinic acetylcholine receptor partial agonist varenicline, and the norepinephrine-dopamine reuptake inhibitor bupropion

Consequently, the initiation and maintenance of nicotine addiction may require exposure to additional reinforcers that are added to tobacco products ( The anti-irritant and cooling effects of menthol are through activation of the transient receptor potential melastatin 8 (TRPM8) receptors ( In this study, we present a secondary analysis of plasma MG concentrations that were measured in a prior analysis examining acute responses to concurrently administered menthol and nicotine in menthol and non-menthol smokers ( Materials and Methods Participants Out of 57 participants who were enrolled in the parent study ( n = 24) and non-menthol ( n = 21) cigarette smokers were enrolled, and previous experience with e-cigarettes was not required