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In the lung ecosystem, virus also plays a pivotal roles in lung diseases, for example, phages could lead to immune-mediated microbial competition [86], opportunistic infection [87], therefore, alterations of lung viral communities could change the bacteriome leading to dysbiosis and disease progression in individuals (e.g., COPD)

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Rolling pipe tobacco can reduce smoking costs by 75-85% compared to factory cigarettes, delivering hundreds or thousands of dollars in annual savings for regular smokers