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Acute Toxicity Fever Anorexia Cardiac arrhythmia Hepatomegaly Chronic Toxicity Liver injury Jaundice, abdominal pain and hepatomegaly May then lead to cirrhosis, ascites and hepatocellular carcinoma Peripheral Neuropathy Sensory and motor nerves affected Peripheral vascular disease Raynauds phenomenon Skin Diffuse/spotted hyperpigmentation (pictured below) Palmar-planter hyperkeratosis Skin cancer Image found here Genetic susceptibility or heritable traits (1,6) Evidence suggests that exposure at a young age can lead to a predisposition to arsenic-induced cancer as an adult There might be a correlation with metabolic diseases and low-moderate levels of arsenic