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Similar content being viewed by others Abbreviations 8-OHdG: 8-Hydroxydeoxyguanosine Akap9: A-kinase anchoring protein 9 Akt: Ak strain transforming AluYb8: Jumping gene AluYb element 8 APC: Adenomatous polyposis coli Arap2: Ankyrin repeat and pH domain 2 ARID2: AT-rich interaction domain 2 ATRX: A-thalassemia mental retardation X-linked protein Bcl-2: B-cell leukemia/lymphoma 2 protein BRAF: Serine/threonine-protein kinase B-Raf CASP8: Cysteinyl aspartate protease CD59: Protectin CD8 + T: Cluster of Differentiation 8 T-cell receptor CDH1: E-cadherin 1 Cdh11: Cadherin 11 CDKN2A: Cyclin-dependent kinase inhibitor 2A CpGIs: CpG islands CREBBP: Cyclic adenosine monophosphate response element-binding protein binding protein CSMD3: CUB and Sushi multiple domain 3 CSp8: Caspase 8 CTNNB1S: Catenin beta 1 DAPK1: Death-associated protein kinase 1 DNA: Deoxyribonucleic acid DNMTs: DNA methyltransferases dsDNA: Double-stranded DNA E2F: E2 factor EBNA: EpsteinBarr nuclear antigen 1 EBV: EpsteinBarr virus EGFR3: Epidermal growth factor receptor 3 Ep300: E1A-binding protein P300 ERK-MAPK: Extracellular signal-regulated kinase ESI: Electrospray ionization FANCD2: FA complementation group D2 FAT1: FAT atypical cadherin 1 FAT2: FAT atypical cadherin 2 Fgf3: Fibroblast growth factor 3 FGFR: Fibroblast growth factor receptor GATA4: GATA-binding protein 4 GATS: Global adult tobacco survey Hjurp: Holiday junction recognition protein HPV: Human papilloma virus H-ras: Harvey rat sarcoma virus IARC: International agency for research on cancer IgA: Immunoglobulin A IgG: Immunoglobulin G IgM: Immunoglobulin M IL-8: Interleukin-8 in-NETO1-1: Neuropilin and tolloid-like 1 ISH: In-situ hybridization IT-MS: Ion trap-mass spectroscopy JAK-STAT: Janus kinase-signal transducer and activator of transcription JNK: Jun N-terminal kinase KMT2A: Lysine methyltransferase 2A KMT2D: Lysine methyltransferase 2D K-ras: Kirsten rat sarcoma viral oncogene homolog LINE1: Long interspersed nuclear element 1 LMP-1: Latent membrane protein 1 lncPSD4-1: Long non-coding RNA PSD4-1 LRE1: Line retro-transposable element 1 LRP1B: LDL receptor-related protein 1B M2BP: Mac-2-binding protein MDM2: Murine double minute 2 MEF2A: Myocyte enhancer factor 2A MGMT: O-6-methyl-DNA transferase miR-181: Micro-RNA- 181 miR-196b: Micro-RNA 196b miR-30a: Micro-RNA 30a miR-934: Micro-RNA 934 miRNAs: Micro-RNAs MLH1: MutL homolog 1 MMP9: Matrix metalloproteinase 9 MRP14: Migration inhibitory factor-related protein 14 mTOR: Mammalian target of rapamycin Muc4: Mucin 4, Cell surface-associated Muc6: Mucin 6, oligomeric mucus/gel-forming MYH1: Myosin heavy chain NAB: Nitrosoanabasine NAT: Nitrosoanatabine NF1: Neurofibromatosis type 1 NF-kB: Nuclear factor kappa B NNAL: 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (3-pyridyl)-1- butanol NNK: 4-Methyl nitrosamino 1,3-pyridyl butanone NNN: Nitrosonornicotine NOTCH1: Neurogenic locus notch homolog protein 1 N-ras: Neuroblastoma RAS viral oncogene homolog NSD1: Nuclear receptor-binding SET domain protein 1 OSCC: Oral squamous cell carcinoma P14(ARF): Tumor suppressor protein 14 alternative reading frame P15INK4B: Cyclin-dependent kinase 4 inhibitor B P16: Protein 16 P16NK4A: P16 Cyclin-dependent kinase inhibitor 4A P53: Protein 53 PABPC1: Poly (A)-binding protein cytoplasmic 1 PCR: Polymerase chain reaction PI3K: Phosphatidylinositol-3-kinase PTEN: Phosphate and TENsin homolog deleted on chromosome 10 QqQ-MS: Triple quadrupole-mass spectroscopy RARB2: Retinoic acid receptor beta 2 RASSF1/2: Ras association domain containing protein 1 Rb: Retinoblastoma RB1: Retinoblastoma 1 RNA: Ribonucleic acid ROS: C-ros oncogene 1 RT-PCR: Reverse transcriptase polymerase chain reaction SLT: Smokeless tobacco SMARCA4: Swi/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 4 SOX17: SRY-box transcription factor 17 Sp110: Sp110 nuclear body protein Sp140: Sp140 nuclear body protein STAG2: Stromal antigen 2 TCGA: The cancer genome atlas TFPI2: Tissue factor pathway inhibitor 2 TKTL1: Transketolase-like-1 TLR9: Toll-like receptor 9 TNF: Tumor necrosis factor TP53: Tumor protein p53 TSC2: Tuberous sclerosis complex TSNA: Tobacco-specific N-nitrosamination VHL: Von HippelLindau syndrome Wnt: Wingless-related integration site ZFHX3: Zinc finger homeobox 3 References Ren ZH, Hu CY, He HR, Li YJ, Lyu J

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