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While its helpful in several cases, prednisone has a handful of unpleasant side effects, including: Mood changes Headaches Slow healing from injuries Fatigue Dizziness Acne Weight gain Swelling in the face and extremities In severe cases, such as noted in a 2017 cohort survey, patients taking prednisone can experience an elevated risk of sepsis which takes as long as 90 days to subside