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According to Professor Bernd Mayer of the Department of Pharmacology and Toxicology at Karl-Franzens University Graz (Austria), Smoking a cigarette results in uptake of approximately 2 mg of nicotine and gives rise to mean arterial plasma concentrations of about 0.03 mg/L (30 ng/mL). Mayer is a known expert on nicotine, but other researchers have slightly different answers

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[1] Smoking has therefore been studied more extensively than any other form of consumption

The synergy between CO-induced hypoxia and nicotines cardiovascular effects creates a dual mechanism for dizziness that smoke-free nicotine products dont produce