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Compared with the CSE+C646 group, the relative expression of p300, H4K12 and CyclinD1 protein after CTPB intervention increased, while TERT and Ki67 protein had no obvious change, which indicated that CTPB could partly affect the relative expression of p300, H4K12, CyclinD1, TERT and Ki67 protein in EPCs

Telomerase is composed of telomerase RNA (TR), telomerase reverse transcriptase (TERT) and telomerase related proteins-1 (TEP1), which is a ribonucleoprotein complex

Configuration method of CSE, C646 and CTPB According to a previously published method, CSE was prepared 9

Histone acetylation occurs at different lysine sites, among which H4K12 can participate in cell aging 32