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Int J Cancer Res (2010) 6(4):188201.10.3923/ijcr.2010.188.201 46 ZeilingerSKhnelBKloppNBaurechtHKleinschmidtAGiegerCet alTobacco smoking leads to extensive genome-wide changes in DNA methylation

This is because, in addition to the harmful effects of nicotine itself, tobacco products contain thousands of chemicals, many of which are known or suspected carcinogens