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Although cholesterol sulfate is present in the epidermis in minor amounts, it plays an important role in epidermal differentiation, skin barrier function and desquamation 30

Due to the wide variety of flavors and marketing tactics that seem to favor younger consumers [7], nowadays, e-cigarettes are frequently used by youth (917 year) [8] and young adults (1824 year) [5], most of whom have never consumed combustible tobacco products [6, 9]