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The surgeon general in 1964, Luther Terry, described the report's effect as a "bombshell." At the time, and for decades afterward, the tobacco industry tried to "poke holes" in research documenting the harms of smoking, Frieden says

Various epidemiological studies have confirmed that smoking is directly and indirectly linked to major causes of death, such as cancer, ischemic heart disease, stroke, and chronic obstructive pulmonary disease (COPD) 7
The airlines should stop distributing free cigarettes to their passengers

In one study, the cytotoxicity of cigarette smoke extract (CSE) containing nicotine (CSE-N) and nicotine-free portion (CSE-O) on human bronchial epithelial cells was studied (BEAS-2B)
