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However, there are some conflicts with the prior literature that should be addressed, some changes and additions to the text and figures that should be incorporated and some aspects of the experimental work that could be extended to strengthen the manuscript

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After MI, continuing smokers have higher risk of recurrent coronary events than smokers who quit (RR 1.51, 95% CI 1.102.07).(29) Continued smoking after a stroke or transient ischemic attack, compared to quitting smoking, increases the 5-year risk of another stroke, MI, or death.(30) Continued smoking after an intervention for coronary artery disease also leads to negative outcomes