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There is considerable debate as to whether these products might deliver nicotine with minimal additional harm to the smoker, becoming a harm reduction instrument that enables smokers to continue their nicotine dependence and reduce risk or enhance quit attempts

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Change history 28 February 2020 A randomized, 1-year follow-up study comparing LAI aripiprazole with LAI paliperidone in patients with psychosis, mostly schizophrenia, and SUD reported a large effect of the change from baseline in the CGI severity score, from 5.9 to 2.4 for LAI aripiprazole and from 5.7 to 2.6 for LAI risperidone [29]

Acknowledgements The author would like to thank Fernando Rico-Villademoros MD (COCIENTE S.L., Madrid, Spain) for his editorial assistance in the preparation of this manuscript