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Key Characteristics of Papyraceous Scars Appearance : Thin, translucent, wrinkled (like parchment paper) Texture : Soft and fragile to touch Color : Often hypopigmented or slightly shiny Common Locations : Knees, elbows, forehead, shins Formation : Develop after minor trauma that wouldnt normally cause significant scarring The Link Between Papyraceous Scarring and Classical EDS In Classical EDS (formerly known as EDS types I and II), defective type V collagen results in abnormal wound healing, poor dermal-epidermal adhesion, and fragile skin that splits easily

Concurrently, somatic mutations in the epithelium and alteration of macrophage phenotype promote inflammation and the development of cancer (carcinoma in situ) that has a high chance of metastatic spread

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