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Dendritic cells and macrophages both have nAChR, which mediates inflammation

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If symptoms do occur, they include fever, fatigue, loss of appetite, abdominal pain including nausea and vomiting, dark urine, pale feces, joint pain, and jaundice (yellowing of skin and whites of eyes)

The Centers for Disease Control and Prevention estimated that of the more than 64,000 US overdose deaths in 2016 from all drugs, more than 20,000 were attributed to synthetic opioids, many of them related to fentanyl and its variations