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In airway epithelial cells treated with CSE and COPD animal models, mTOR inhibitors (such as rapamycin) or AMPK activators (such as metformin, AICAR) have been reported to improve mitochondrial function, reduce ROS levels, alleviate inflammatory infiltration and structural damage, accompanied by upregulation of LC3B-II and enhancement of PINK1/Parkin-mediated mitophagy (296)

Drawbacks: Residual Smell: While heated tobacco products produce less odor than cigarettes, they still have a lingering smell

Some people believe it's a safe alternative to smoking since it isn't linked to lung cancer

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