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RESULTS We utilized single nucleotide polymorphisms (SNPs) as genetic instruments for irritability, smoking status, and bipolar disorder, identifying 29, 37, and 91 SNPs, respectively, after the screening process, as detailed in Table 1

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When UVR-induced DNA damage occurs before entry into the S phase, p53 halts the cell cycle at the G1 phase in part by transcriptionally inducing cyclin-dependent kinase inhibitor ( CDKN1A) , also known as p21 (WAF1/CIP1), a potent inhibitor of several cyclin-dependent kinase complexes

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