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Total blood sampling volume for each subject throughout the duration of the study included the following: 25 mL for clinical laboratory tests (both screening and end of study or at early termination) for each of the non-menthol and menthol groups, and approximately 460 mL (15 tubes 6 mL 5 test sessions, plus additional 10 mL) and 550 mL (15 tubes 6 mL 6 test sessions, plus additional 10 mL) for the non-menthol and menthol groups, respectively, for plasma nicotine assessments

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