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Animal data suggest that damage to dopamine pathways and, especially, serotonin pathways is morphological and partly irreversible

Studies indicate that nicotine may contribute to lower testosterone levels

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According to a December 2023 study by researchers in Argentina, led by Omar De Santi, toxicologist at the Posadas National Hospital in Buenos Aires, clinical trials have shown that cytisine pills were more than twice as likely to successfully help participants quit smoking compared with those taking a placebo