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Day 1: October 22, 2018 Transcript: Welcome: Mitch Zeller FDA Center for Tobacco Products Opening Remarks: Jeff Walker Teton Regulatory Sciences Overview of the Meeting: Eshael Johnson Office of the Center Director (OCD) Session 1: Request for Exemption from Substantial Equivalence (Exemption Request, EX REQ): Jennifer Schmitz Office of Science (OS)/Division of Regulatory Project Management Substantial Equivalence: Cristi Stark OS/Division of Regulatory Project Management Panel Discussion: Moderator: Eshael Johnson OCD Brittani Cushman Turning Point Brands Thomas Lindegaard Scandinavian Tobacco Group Patrick Murphy RAIS Rosanna Beltre OS/Division of Regulatory Project Management Cristi Stark OS/Division of Regulatory Project Management Session 2: Premarket Tobacco Product Application (PMTA) Review Process: Nicholas Hasbrouck - OS/Division of Regulatory Project Management Modified Risk Tobacco Product (MRTP) Application Review Process: Ebony Jackson OS/Division of Regulatory Project Management Session 3: Pre-Submission Meetings with the Office of Science: Barbara Banchero OS/Division of Regulatory Project Management Tobacco Product Master Files (TPMFs): Sarah Vichensont OS/Division of Regulatory Project Management Panel Discussion: Moderator: Karin Rudolph OCD Bryan Haynes Troutman Sanders Patricia Miller Altria Russell Wolz Enthalpy Analytical Marcella Dolling - OS/Division of Regulatory Project Management Joanna Randazzo OS/Science Policy Branch Session 4: Information and Resources on Application Review Programs: Sharyn Miller OS/Division of Regulatory Project Management CTP Electronic Submissions Standards and Activities: Jeff Smith OS/Division of Regulatory Science Informatics Panel Discussion: Moderator: Karin Rudolph Leann Campbell RAIS Paisley Cameron JTI Anuschka Merson ITG Brands Sharyn Miller OS/Division of Regulatory Project Management Deborah Sholtes OS/Division of Regulatory Science Informatics Session 5 Environmental Assessments & Claims of Categorical Exclusion: Hoshing Chang OS/Division of Nonclinical Science Transfer of ownership - Renee Coneway OS/Division of Regulatory Project Management Panel Discussion: Moderator: Eshael Johnson OCD Tony Abboud Vapor Technology Association Karen Cook ITG Brands Christie Day 1 Presentation Recordings Session 1 Sessions 2 & 3 Sessions 3 & 4 & 5 Day 2: October 23, 2018 Transcript: Welcome: Karin Rudolph OCD Session 6 Content Focus: Request for Exemption from Substantial Equivalence (Exemption Requests) - Matt Walters-OS/Division of Product Science SE Report Content: Colleen Rogers OS/Division of Product Science Todd Cecil - OS/Division of Product Science Panel Discussion Moderator: Eshael Johnson - OCD Robert Buell Altria Thomas Lindegaard Scandinavian Tobacco Group Marc Scheineson Alston & Bird Todd Cecil OS/Division of Product Science Colleen Rogers OS/Division of Product Science Matt Walters OS/Division of Product Science Session 7 Premarket Tobacco Product Application Content Overview: Iilun Murphy OS/Division of Individual Health Science Tobacco Product Application Review: Modified Risk Tobacco Product Applications (MRTPAs): Ben Apelberg OS/Division of Population Health Science Panel Discussion Moderator: Karin Rudolph OCD Debbie Hayden SMNA Matt Myers Campaign for Tobacco-Free Kids Elaine Round RAIS Mohamadi Sarkar Altria Ben Apelberg OS/Division of Population Health Science Priscilla Callahan-Lyon OS/Division of Individual Health Science Session 8 Open Discussion on Newly Deemed Tobacco Products Panel Discussion Moderator: Eshael Johnson - OCD David Graham NJOY Drew Newman J.C

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One common issue among cannabis vapers is a sore throat, which can be caused by a variety of factors, including the ingredients in vape cartridges and the way vaping affects the throat and respiratory system

The interaction between the carcinogenic effects of smoking and radiation was significantly stronger than multiplicative, and the low lung cancer rate found among women with HD was attributable to the delayed popularity of smoking among Dutch women, a fact shown by the male/female lung cancer ratio (13:5) in the Netherlands in 1980