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Tobacco smoke has been shown to inhibit CYP2A6, leading to a decrease or at least a slowdown in nicotine metabolism in smokers compared to non-smokers (Lee et al., 1987

Concluded the study group, The sum total of scientific evidence establishes beyond reasonable doubt that cigarette smoking is a causative factor in the rapidly increasing incidence of epidermoid carcinoma (cancer) of the lung. The response of the tobacco industry was substantially what one might expect from a $5 billion-per-year business that pockets more than $170 million annual profit and pays its top executives yearly salaries in excess of $400,000