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Nicotine actually comes from the roots of the plant, though they are thought to come from the leaves

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Concurrently, innovations in metabolite detection technologies, such as liquid chromatographymass spectrometry (LCMS) and gas chromatographymass spectrometry (GCMS), along with the continuous optimization of analytical tools, have led to an astonishing expansion in metabolomics data, ushering in the unprecedented era of big data