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The presence of previous buckling surgery is a relative contraindication for local anesthesia, since the presence of the buckle and surrounding scar tissue can prevent the effective dissemination of the anesthetic
NRT products, including transdermal patches, gums, lozenges, nasal sprays, and inhalers, collectively generated revenues of approximately $3.1 billion globally in 2025, with the segment growing at over 4.5% annually as smoking prevalence in developing markets sustains cessation demand and new market entrants expand NRT accessibility in emerging economies
