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They may trigger allergy-like symptoms, such as watery eyes, sneezing, or wheezing

Opportunistic infections due to bacterial, mycobacterial, invasive fungal, viral, parasitic, or other opportunistic pathogens including aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, histoplasmosis, legionellosis, listeriosis, pneumocystosis and tuberculosis have been reported with TNF blockers

Most fusions (for example, those involving ALK, ROS1 or RET ) are detectable with break-apart FISH assays or hybrid capture-based NGS, and DNA-based NGS has been used to identify novel fusion partners not detectable with FISH and reverse transcription PCR 80

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