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With at least 567 federally recognized tribes across the U.S, interventions to reduce commercial tobacco use will vary in strategy and approach, with the most successful likely being culturally specific and community-based

The liquid in e-cigarettes have widely different nicotine concentrations, varying from 8 to 24 mg/ml per cartridge, but even doses up to 100 mg/ml are readily available [28] and pose a real risk of nicotine poisoning [29]