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In Fleming's first novel Casino Royale (1953), Bond's cigarette of choice is "a Balkan and Turkish mixture made for him by Morlands of Grosvenor Street." Fleming personally disliked cigars and would use cigar smoke as an image of sadness or cheapness in some of his works
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Clonidine is an a2-adrenergic agonistand is used as an antihypertensive medication, which decreases sympathetic outflow and acts on the central nervous system may reduce withdrawal symptoms associated with tobacco use disorder
