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While the instrument used for outcome measurement was varied from depending on self-report and dairies either written or electronic solely or accompanied with validation test such as taking urine specimen for anabasine and antabine as a biochemical confirmation of OST abstinence, Fagerstrm test for nicotine dependence-OST (FTND-ST) which was modified to specifically measure OST nicotine dependence level, or the OST abstinence rate was validated with saliva cotinine test

According to the Centers for Disease Control and Prevention (CDC), the prevalence of smoking dropped from 20.9% in 2005 to 13.7% in 2018

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