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Because so little is known about the causes of LCINS, there may be a tendency to overstate the importance of associations with potential risk factors that have been studied, rather than acknowledge that the findings of these studies are unlikely to account for a large proportion of LCINS

Beginning in 2002, an American-Swedish research group used a World Health Organization database to describe in detail the impact of snus use on smoking among the population in northern Sweden during the period 19862004 [46, 143, 144]

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